
Folic acid is a water-s✔ ♠oluble vitamin, also kn₩≤ own as vitamin B9. In the folic acid metabo←Ωlism pathway, single nuc≤☆∑♣leotide polymorphisms (SNP§±±s) of methylenetetrahydrofolate reductase (M¶"€THFR) and methionine sy< nthetase (MTRR) can affect the activity of ≈¥ <MTHFR and MTRR enzymes a £nd can affect Serum folate and homocysteine↕♠ levels. It will lea∏≤d to hypofolateemia and♣×× hyperhomopenic acidemia, thereby increasin↓ g the risk of neonatal birth d®βefects, neural tube diseases' ± and cardiovascular disea≥λ& ses.
Folic acid gene testing can p™≥♣rovide guidance for people who lack≤β folic acid due to genetic factors to achieve pφ÷>∑recise medication; prov★Ω"ide the basis for the onsetγ of patients with hyperhomocysteinemia; defin§©★♥e family genetic history, andβ↔ provide guidance for eugenics and personali&®zed medication.
Date:2020-03-26
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