In the folic ♣'β€acid metabolism pathway, single nucleot♥♦↕ide polymorphisms (SNPs) of methylenet$•etrahydrofolate reductase (MTHFR) and methionin✘Ω♦e synthetase reductase (MTRR) can affectπ the activity of MTHFR and MTRR s∞§≠♥ynthase, and Affects the level of s♠"♥erum folic acid or homocysteine. It will cause§$÷ hypofolate and hyperhomocysteinemia, w ✘←₽hich will increase the risk of birthα∑ defects, neural tube d↔ ↔Ωiseases and cardiovascular↓☆ε≈ diseases in newborns.
The "China Cardiovascular Disease 2015" re§↓ port shows that: China's cardi$±ovascular disease accounts for the hi¥Ω♣ghest mortality rate of residents in China, and< ÷× the number of cardiovascular patients will con↑✔δ₩tinue to increase in th☆≈₩αe next ten years. At the₩÷δ same time, there are about 8₩↔00-1.2 million new cases of σ★♦birth defects in China every year. The$"<®refore, folic acid gene testing is carried ou★Ωt to personalize folic aci₩♠•d supplementation for people with folic ♣↕acid mutations, so as to fundamenta★lly prevent the risks of birth defects, n↓ eural tube diseases and cardio☆∑ vascular diseases.
Figure 1: Methyltetrahydrolysis (MTHFR)gene C₹'✔§677T(rs1801133)
Figure 2: Methyl tetrahyd×≥ε✔rofolilic acid reductase (MTHFR)MTHFRgene←→ A1298C(rs1801131)
Figure 3: Methylthion syntε£λ←hetic reductase (MTR✘≈↕R)MTRRgene A66G(rs1801394)
High sensitivity:&nbs↑αp;The detection limit of the genomic DNA of the exa≈®¥↔minee is 2ng / μL；
National 973 project, top international and dom>©≠♣estic experts devote themselves to creatin↕♠g
Detection of specimens:φ♥'φ Anticoagulant whole bl>₩↕ood or genomic DNA
Technical principle: PCR-fluorescent melting method
Packing size:24 tests / kit,48 tests / kit
Category:In vitro diagnostic <÷φσreagents
Suitable for instruments: Fluorescence quantitativ♣↕★e PCR instrument
Date:2020-03-26
Date:2020-03-30
Date:2020-03-17
Date:2020-03-11
Date:2020-03-03
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